	   SnapGene      ›GCTAGCCAACAAAGCGACGTTGTGTCTCAAAATCTCTGATGTTACATTGCACAAGATAAAAATATATCATCATGAACAATAAAACTGTCTGCTTACATAAACAGTAATACAAGGGGTGTTATGAGCCATATTCAACGGGAAACGTCTTGCTCGAGGCCGCGATTAAATTCCAACATGGATGCTGATTTATATGGGTATAAATGGGCTCGCGATAATGTCGGGCAATCAGGTGCGACAATCTATCGCTTGTATGGGAAGCCCCATGCGCCAGAGTTGTTTCTGAAACATGGCAAAGGTAGCGTTGCCAATGATGTTACAGATGAGATGGTCAGACTAAACTGGCTGACGGAATTTATGCCTCTTCCGACCATCAAGCATTTTATCCGTACTCCTGATGATGCATGGTTACTCACCACTGCGATCCCCGGGAAAACAGCATTCCAGGTATTAGAAGAATATCCTGATTCAGGTGAAAATATTGTTGATGCGCTGGCAGTGTTCCTGCGCCGGTTGCATTCGATTCCTGTTTGTAATTGTCCTTTTAACAGCGATCGCGTATTTCGTCTCGCTCAGGCGCAATCACGAATGAATAACGGTTTGGTTGATGCGAGTGATTTTGATGACGAGCGTAATGGCTGGCCTGTTGAACAAGTCTGGAAAGAAATGCATAATCTTTTGCCATTCTCACCGGATTCAGTCGTCACTCATGGTGATTTCTCACTTGATAACCTTATTTTTGACGAGGGGAAATTAATAGGTTGTATTGATGTTGGACGAGTCGGAATCGCAGACCGATACCAGGATCTTGCCATCCTATGGAACTGCCTCGGTGAGTTTTCTCCTTCATTACAGAAACGGCTTTTTCAAAAATATGGTATTGATAATCCTGATATGAATAAATTGCAGTTTCATTTGATGCTCGATGAGTTTTTCTAATCAGAATTGGTTAATTGGTTGTAACACTGGCAGAGCATTACGCTGACTTGACGGGACGGCGGCTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGATCACGCATCTTCCCGACAACGCAGACCGTTCCGTGGCAAAGCAAAAGTTCAAAATCACCAACTGGTCCACCTACAACAAAGCTCTCATCAACCGTGGCTCCCTCACTTTCTGGCTGGATGATGGGGCGATTCAGGCCTGGTATGAGTCAGCAACACCTTCTTCACGAGGCAGACCTCACTAGTTCCACTGAGCGTCAGACCCCGTAGAAAAGATCAAAGGATCTTCTTGAGATCCTTTTTTTCTGCGCGTAATCTGCTGCTTGCAAACAAAAAAACCACCGCTACCAGCGGTGGTTTGTTTGCCGGATCAAGAGCTACCAACTCTTTTTCCGAAGGTAACTGGCTTCAGCAGAGCGCAGATACCAAATACTGTCCTTCTAGTGTAGCCGTAGTTAGGCCACCACTTCAAGAACTCTGTAGCACCGCCTACATACCTCGCTCTGCTAATCCTGTTACCAGTGGCTGCTGCCAGTGGCGATAAGTCGTGTCTTACCGGGTTGGACTCAAGACGATAGTTACCGGATAAGGCGCAGCGGTCGGGCTGAACGGGGGGTTCGTGCACACAGCCCAGCTTGGAGCGAACGACCTACACCGAACTGAGATACCTACAGCGTGAGCATTGAGAAAGCGCCACGCTTCCCGAAGGGAGAAAGGCGGACAGGTATCCGGTAAGCGGCAGGGTCGGAACAGGAGAGCGCACGAGGGAGCTTCCAGGGGGAAACGCCTGGTATCTTTATAGTCCTGTCGGGTTTCGCCACCTCTGACTTGAGCGTCGATTTTTGTGATGCTCGTCAGGGGGGCGGAGCCTATGGAAAAACGCCAGCAACGCGGCCTTTTTACGGTTCCTGGCCTTTTGCTGGCCTTTTGCTCACATGTTCTTTCCTGCGTTATCCCCTGATTCTGTGGATAACCGTATTACCGCCTTTGAGTGAGCTGATACCGCTCGCCGCAGCCGAACGACCGAGCGCAACGCGTGAGCCCACCAGCTCCGTAAGTTCGGGTGCTGTGTGGCTCGTACCCGCGCATTCAGGCGGCAGGGGGTCTAACGGGTCTAAGGCGGCGTGTACGGCCGCCACAGCGGCTCTTAGCGGCCCGGAAACGTCCTCGAAACGACGCATGTGTTCCTCCTGGTTGGTACAGGTGGTTGGGGGTGCTCGGCTGTCGCTGGTGTTTCATCATCAGGGCTCGACGGGAGAGCGGGGGAGTGTGCAGTTGTGGGGTGGCCCCTCAGCGAAATATCTGACTTGGAGCTCGTGTCGGACCATACACCGGTGATTAATCGTGGTTTATTATCAAGCGTGAGCCACGTCGCCGACGAATTTGAGCAGCTCTGGCTGCCGTACTGGTCCCTGGCAAGCGACGATCTGCTCGAGGGGATCTACCGCCAAAGCCGCGCGTCGGCCCTAGGCCGCCGGTACATCGAGGCGAACCCAACAGCGCTGGCAAACCTGCTGGTCGTGGACGTAGACCATCCAGACGCAGCGCTCCGAGCGCTCAGCGCCCGGGGGTCCCATCCGCTGCCCAACGCGATCGTGGGCAATCGCGCCAACGGCCACGCACACGCAGTGTGGGCACTCAACGCCCCTGTTCCACGCACCGAATACGCGCGGCGTAAGCCGCTCGCATACATGGCGGCGTGCGCCGAAGGCCTTCGGCGCGCCGTCGATGGCGACCGCAGTTACTCAGGCCTCATGACCAAAAACCCCGGCCACATCGCCTGGGAAACGGAATGGCTCCACTCAGATCTCTACACACTCAGCCACATCGAGGCCGAGCTCGGCGCGAACATGCCACCGCCGCGCTGGCGTCAGCAGACCACGTACAAAGCGGCTCCGACGCCGCTAGGGCGGAATTGCGCACTGTTCGATTCCGTCAGGTTGTGGGCCTATCTTCCCGCCCTCATGCGGATCTACCTGCCGACCCGGAACGTGGACGGACTCGGCCGCGCGATCTATGCCGAGTGCCACGCGCGAAACGCCGAATTTCCGTGCAACGACGTGTGTCCCGGACCGCTACCGGACAGCGAGGTCCGCGCCATCGCCAACAGCATTTGGCGTTGGATCACAACCAAGTCGCGCATTTGGGCGGACGGGATCGTGGTCTACGAGGCCACACTCAGTGCGCGCCATGCGGCCATCTCGCGGAAGGGCGCAGCAGCGCGCACGGCGGCGAGCACAGTTGCGCGGCGCGCAAAGTCCGCGTCAGCCATGGAGGCATTGCTATGAGCGACGGCTACAGCGACGGCTACAGCGACGGCTACAACTGGCAGCCGACTGTCCGCAAAAAGCGGCGCGTGACCGCCGCCGAAGGCGCTCGAATCACCGGACTATCCGAACGCCACGTCGTCCGGCTCGTGGCGCAGGAACGCAGCGAGTGGTTCGCCGAGCAGGCTGCACGCCGCGAACGCATCCGCGCCTATCACGACGACGAGGGCCACTCTTGGCCGCAAACGGCCAAACATTTCGGGCTGCATCTGGACACCGTTAAGCGACTCGGCTATCGGGCGAGGAAAGAGCGTGCGGCAGAACAGGAAGCGGCTCAAAAGGCCCACAACGAAGCCGACAATCCACCGCTGTTCTAACGCAATTGGGGAGCGGGTGTCGCGGGGGTTCCGTGGGGGGTTCCGTTGCAACGGGTCGGACAGGTAAAAGTCCTGGTAGACGCTAGTTTTCTGGTTTGGGCCATGCCTGTCTCGTTGCGTGTTTCGTTGCGTCCGTTTTGAATACCAGCCAGACGAGACGGGGTTCTACGAATCTTGGTCGATACCAAGCCATTTCCGCTGAATATCGTGGAGCTCACCGCCAGAATCGGTGGTTGTGGTGATGTACGTGGCGAACTCCGTTGTAGTGCTTGTGGTGGCATCCGTGGCGCGGCCGCGGTACCAGATCTTTAAATCTAGAGGTGACCACAACGACGCGCCCGCTTTGATCGGGGACGTCTGCGGCCGACCATTTACGGGTCTTGTTGTCGTTGGCGGTCATGGGCCGAACATACTCACCCGGATCGGAGGGCCGAGGACAAGGTCGAACGAGGGGCATGACCCGGTGCGGGGCTTCTTGCACTCGGCATAGGCGAGTGCTAAGAATAACGTTGGCACTCGCGACCGGTGAGTCGTAGGTCGGGACGGTGAGGCCAGGCCCGTCGTCGCAGCGAGTGGCAGCGAGGACAACTTGAGCCGTCCGTCGCGGGCACTGCGCCCGGCCAGCGTAAGTAGCGGGGTTGCCGTCACCCGGTGACCCCCGGTTTCATCCCCGATCCGGAGGAATCACTTCGCAATGGCCAAGACAATTGCGGATCCAGCTGCAGAATTCGAAGCTTatgcatcatcaccatcaccattgaGTCGACGTAGTTAACTAGCGTACGATCGACTGCCAGGCATCAAATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTATCTGTTGTTTGTCCGGCCATCATGGCCGCGGTGATCA  )7                                        !         %                                          
                           
   
                  
         $          +                           $   &            
               
                  *                                                !                              
                                                   
         	            
   	            #                  	                                 	         
         	      	                                       
                                                      
      
      
            &                           &         #            "         
                                                	                           	            "                  	                  
          p ç‹456ÚÛ+,-‹Œ¿ÀÑm	ð	ñ	-=>HIJÅƒèù  ˆ ü ªèÜ•ÏÜ·Án	È
;.„A q À ÿ7·û÷(�Òò	4?KZÆ�¡ Ê Û Œ+.®
2
Ej3s�±Ö‡¶Ñéúƒf O–ÂÐ2¸Âï²/÷ÎË ‰ ý [«�é1¼Ý;WÉ
Ï
I”oJÜòÎ ° ± 	„ëA™o	‚<Éí Ý ûÄ	›Ÿçò7$¼_…ØBl r ä ÔÄ<2ø„ŽŸÓ	5
7eô2F°’ Á &»i›_¥¬ç~–	dpN “üRWô°¸5 8üYz‡	dX@L‚Ç¢º FP'¸ )Q	¾	ó	ûC[Öž°Þ=! <á�ê�/03 	Y
o
r
†
”
F4t…ˆ™D×C­ Ü  ëÄ3¸³X	²	
3
µéé:ê	%d„B Ë TyXäp€fÝ,H•¯E	Ô
5ÇÓß=e²ÏøûU% š }–œN`k<RÖˆ	�	

¦
»
ù
k¥Ld�š¤ˆH�·ÒKP�ÞgƒŒ ˜ å¶Ík	ž	÷
ùJ³�ÚcÏÖæIjÌ Aõg~—Ã¹À `?œ ¯Ã·T5` z pÈÎHpPwÅÑ3³Óà»ð%	;	á	ý
‹À`á0øu þ Â\’|
pó  Š ¬×�”êSß€™Þ<XcáÊ
ÄÝQ^ \ÅGK}«í5	O
Ð
JÌ±ÏîÏú I …2öª0Tb½Ë£	•-Krí"»â % ± 5>C‰Œã[jý’™…ˆ ‘
 6 Ò Óoxwíiš¸Ú   · Îd²Ç�‘
	Z £%!
äì÷Bb	p		
ß
ƒ­=UÊÆî6•  XmâÙÞh´2	_	Å	Ô	;œÛ8ÄÐÜ‡Št½Âq†C"
 é ¡ó½`Ùmä KÔê ð%Ê:b m(¼ÖXÏüË	—
®
&�èh“ï.³ 1n3Ûè— …ÏÔ	Â	
0
h™ABVFõ58Ab ÕbÅ=u±Þ	#	f3G±“  s ï�õþ6o Åö.
Þà6œ å =ù�Çu
¹ÔWå/õ 'Ü�•±È	q,:›% g t¼	`­ï\
e—
 Â ø ¼+øjœ¦è¡
 �8L	—	,O2  ,àýX‚õ ¹ê{ˆÌe’R—£)¤ª"£x ( u 8”±˜Ô‡ž
Ã( SA‰ž6:ý¢	{ƒž¬»o{ ñ,?Æ9Z{óqC
VYAMÈ Ø ¸	ò(¹ø™ø,	…	¿	Ž
(68\×§ß7>UX~[
 G»¢Ò'`©±©  V � 2‹÷!*D’‰Ÿ Q„ó]R	ô	âü£ô9k¨z$ â0%ž±0L1FP½W
p
3G€5bm†—ÿçö2;FL�®÷�žë�   ž Ð ç ¡#^ŽëRß]	¡	
•
«Â÷‰ÂÎÚRpÈØ ,^h *)rÐs…Ü4!	ƒ	Z
s
§ãš¦•0+ æ÷=r „ÇÕ�	­	Ú	ã	ê	
U
w
‡
‰
O©À +Y[u}•šœE|DtŠ ì†Å%¹mt"´ÅÉ=	×	+
›
#wzêGObê[e÷ Ý !?49¦G×Y	³	
Öžøž'UÙ v�³ ™Êykg
-¶v¶;ë
	C 0 ´?É%
4
J
Q��i&… ´ UèzÑþ�Þá-hµû–œF	¯	»	ý	f³ëô   )JËAì»ÈÔàÐw Z ô YågK‹Ó1zü ” Ì 7•aqÆ#s¾êI‘°ò@	g	Ü	å	c
Õ
ÿ
6>ùúV$ › ù>’ÂÈ=/	I	~	�	“	`
y
‹
ú
>Œ¦´Éí]m›I�¸Ów¦�&  | 
/¥'�ä†C@'	x	
 
¼
ï
»M]e­1‘¥‰¹âL‘ß>„ d~7—¹ã5Oal©€
§
Ä
l~Žh FâS×‰	ì	 
=
xvQŒ o æ”¶ÎÙ*­l	DrŽÐç
 êÁIÛñ×kÍ ã %ºÓó^¤ƒcúcdÝ< ™ ;•·›œ/Ž	Ÿ	~
¥
ø
K´d JOAT ÇGoÄºàb ÁÄ“RªÞ©˜ìù
 5 =BãövhÞ
T J'»ÕÊ	Ó	%s¼Áãa îaŒÚç°Ä-
¸VU.a f š @ˆ�>Å—òË�
‘z' Š·¡ñò'¢j6Z*  )"qÏ/q$Qrƒ°ÆÔEO¼Þ 	\	¬	Ù	â	é	2ö|ÁÍÙþQÇâõ1]g”�/ u²É8¥l³xF<	"yŒa `IJÒ´éñ?	þ
ùó  {  ‘E4Çá&	}	_
î
¬ì¸áv n $é]“›.}
qÿÜS 4 Ã’âF¨
ßâ` ‰=ðñ&¡i™  ÿ t7_‚¯	[	|	^
1ýÆôà 
 #‘6<^áè�š{	0 üÞþhR_  9 : P ­Øab;Cà =>²
³
úûýgL  ; ¤ Æ Ù•ëc�ñD}â\H Q b ‹ O®T!ß?Ydµ	´
Ë
Å ¨M Ç Õ 2Hv–Ñ
Û < M i ÆÚLðd~î~ãP
²ïI ¥ ]ì‚¬´6	KÍ)çû  ß ì A�r¦òEÎ	
Ð]Ð! … Œ OU"1Uà@IÌÙ%Ze

:
Ì
–ÆØ.Ls¡$WnãN  J c « ¯†¾[¨¾©		©î¼ R P3÷LPb«cå#p+ Öj"�¤	¶	µ
" ® ¾ È ú D‘wÂ/g‰9m
’
Ò
°´ÜŠ G x 3?ŠIk{š†ž¬
¾í & Ö 6þym ² b�ä\—“!~²`Œ ñð 7 N ` Ä Ó M›Ôpïî›J
 = ?  ¼ ÇÛeyäð j x¿j¹ 	Q
i
³Û¿ - Ýúlƒ­µ{L¸*è ¡ ¾íMÌ£		 ¸ ^x-eÈÜŽ7	Î/¬å— � ¦ µÏ¨³‘’[ü ñ &ó	›	


Á
ô
>Óò€Ë7 A D à qB§FgåC§ª	‚ÑE‡–  í ž"íêæc	q	à
p„®h¸ÑV^t }¤É*søÏ¨ŠÏ	ù	)x=ÀÇï † YPVÚß2W&:µ
Í
�9ƒÅÑÝ¢XÃ›D Enã´VËÍf3	`	ÙH…ˆ‹	¾Íoä4O  � [*	Æ	*—Ü4‡ # Ï#‰áAJÚiÕ	
#
)
;
H
S
<¾Ç/Mkt%ur d ;° PCp¢¿C�ª	ô�Ë×ïa  2 K l ê ‡ Y\. ãlÚnå + ^ ¬ ½w™	k
¿
ò

ª½
 ¿©A]	'
æ
è
P¾ S Qž4ÁMËc�dN	Sæñ‡;c LÂ&,	 ÏÕøy£ëqÔ ƒ—¾Q¬6
¡
Ú
ê
¡R”Ë$Á( ®)k&¶ü_ž¦»Ð	u	L
˜
éï	!Àþ/ n›I#,Mz ×æýÌ	¯
'#µÝQi”
 ×U«½ÁYl·	ˆ	 ×	¥	¶
�Åð¬´ ¿ É û ŠŠÐ
1
Ç
i2,G†µe ¯ Ž0ƒN:˜îÃ	š±»ö E’VÃh¯·Oš4æy}†ž	P	½	BWo�Õ6# Sêx|Ã2oeÜé_jÕD	W	±	n
“
Ó
èC™9B¬$cÝ‹ y @>› ŸÍôfv}®²ß$	:	¿4Ht H ÖJ„|ì/°í $ ¶ 4ˆ‹ÍâZciÆÒünw‘‡�·		~” WláÓØ
é­
gî²  –ýÿnÆÎ/
gß4	 ÷ ÷»Ž°7+ ' t 7ßð�ÿé9Ózp¡B
U�£wz  U × ƒö÷˜÷áó7‘¦~ æ  åö]„v
NXa”æ™¥Œö‰ê / Žÿ˜…>ÈÕhµTö Y “ ³ ”ýÊà"grú�f	º	º0 .c¤&6=ãH	ÿ	‹³º�¥= òš�	C; ÀÝÉ	ra Ä‹–ñy-&  (�²Nœ.	 ï®ð-]
Å˜ 8 O a £ Å N€ðf[K h Ô uœïq¥³
Í	
 NÕ½aœ$#* w ½ ù a.fz�8±½ > » Ã ï	 € ½Ü,Ûùk¢	 @ ð |È§é‰å	o(�Òñs	 ÎV9R
GÌš3 * ] k :OX¼\o€	˜	j
å
-ÊÖâ ‚–€M	 
À +LyÀÖûk¥ºt	‡î´ÜP U®¶M|‰í1˜+…Ô«# áYhƒÑàûm�×ëó|­9	¯}s  ö Þöºè8Íf*3¢¥y} . ’ -þ£%„ü<fqM“¹S˜¤¤é ¿™M ¢ î²	ÄZ) v º `{Úîˆ		r ) \ 9•NÍÕúU¤Ÿ
™ Tg¢ß�çû7;ep¬8	0„®||
 ¹ _zíT	Y˜q yf¡ÝÞB[\Ÿ úüýþÿUVRSdo|­p .ÉC]Š¡{ Wþ£Ï­}Ÿæ¼k /:ÿôƒ
WZ® Öýl ‚ Ð´J^‹@’±i¥¤½ ©ÊD¢|®ðˆ|“ ~Éþ § i¶ò-ÇX�Õ[€rD
\sÐBNç Ù 
:)ºùõ“ù†	„
£¯ÍÔ]�Ì? – —ôa²i	œ	�
õ
XØàþ 8\ 0¹ó;%ô	À	
?7@•¡ó¨8Vm Î ò '5Ä Àš-	
e
Â
)k[9*Y× á HÑ9µ¨“£Ój(«Üç	£
Ü
ì
 aTªX  ƒ r_AhæD¦	8
ûF B E ÀKŒe¥¨ª
|²¾ˆ ™C¬¼ÍGw²ÀuƒüÃªÒ " W Œ}®È”çB	d	¹Šu î £‰"+r	ã
…¯E!Ê_ � gŸ#¯îñSøë}Kq–ÒW ÿ
    3ªËEcá
i“ j~.Y©ìÞ	ú	8]Ñý¤õ*:yCO©è&>{È€
 ¨ ·RÈÖÐ	E
×
ð …Êó	+Gtù…Ðô\�^svl
 ¥sŽ‹S	õ	tãÁ ‡ Ú ©Ûþ*3úö'¶¾ï	:°Õ3<YÄ‚œø@‚Ÿ Z°@Ÿ»1VúÎ
H�“žæñ6n#^ÈÍÊì ûQ;1&«X	•		M¯ó1E¯¹‘& Wàã²M2;GQ”‡	
X
q
…
º
4¤c„‡˜ÆÒÞ <£Îè÷GŽ�‚ — _oäµÌÒj	�	à	ö
ü
¶øIŠS_ŒÙ¿Õå_i Fõ[Sa‘Êbà4	¢	N
{
ÃË,q
Î!ºáÿP] Ÿ Ñ ¢$˜�ìa	
�
Y¬ÙÅ5  è lWÎg³1	^	–
:ŽÚÃÏÛï†‰Ép’-!9 0mô<tÝ5õ	"	Á	
t
˜ÓÝ@AäE›ô@ €*sÛ” îK	Ç	[
+9–$1  ++†ÂQ–¢«(©!n Ž 1ºÑ&\+	„	�
_¨58§ˆTWy}¨& � Ï (KÛ€	‚	

T
V
ˆ
¨ª¿Áÿ*Zl~–›¦o{:EKs+€� >$s!ÈÄÖjÖ	$
*
I
f
š
P,v€�÷FNu�&ZØ ó ç6Ð(ÅŠ½›®	Û	ä	ü	b
@ëvêy# 	ø¸…âB¨Á?.	w	’	ë	
<
x
Š
Ã
=wÈ\0\l} u‹ â ¹Ò:”£µÀØ)‚¬¤
bHcðbN@ <IQ©Æ&ºÔnuÒ	Ý
$ë»Sø e í¶‡ÙæÊ,
œ
U�Y" ±!¤.k#DIqEÆèDÝ>	«	Ø	è	í
!õx{«ÌØëP·\f“ò 3 m sˆE§		Z	%ßÛá 	  "`5:B]ç|z	´	±
/ŸùŸ§üG
 L Þ ë 1@
(Úæ  „ ª !KZi§OHØ¨	

9
×
!äVmo F ­ �Áxll
«
}_¯‹³ì‰ _ ~ š¾ÿh
¾ , w´§L�Ëz.·«ä– C p)f¦©š	Î	ø	À
ó
gw·<¿
D† D³ˆÊ)	"
(
G
)½‚3j„ 1 @BvB&
¾
ç
ñ
OŽk �½ÎÀxÁÊ¢5
Ù
é
RQ“'†Ó š­HTª%Ÿµ^å	K
 ¿ýÄ« Ré{�ÂN~‚™då^ix�C	O	V	°	¼	Æ
çºn€d # µ V‡ÌvÒÿÌ.e	�¶èì T €‚¯Òö•ü—A
Tò�v X Ÿõ5ÉßâƒG	e	¹	þ	Šg´‹ˆõ<  ÃŠŒ	Bx`- M¤Ì#,"	 ï -7n°¼'€Ñ W*K»[ns	ä
†íFÉÕáË ‘ õ Ð$ÖòLì—Ó2¡ r [ ÙùL  ZæùzûTìQcn~«X{j hI­°ïh‡¤ŒÔ‚
rýÕ • Í 49–Ã$¿`’±óh	d
 ¢j?Ì”)  ˜8«¿Ìdv¿tÛæ	7
¢
©
Û
ë
{SúûÂW ! fbR­ÇJA	â
•	 „FrëuÝ	Ö
7% ¨ú¯?ýªU	”	î	¹
’åð";Çò0Ž®¸É� kZ`�ÉÑ0	ß	M
z
û
9�µÊî+^‘¹ÔÄ */lÚ“ŸíJ	Œ
^ÒÁDPª'?Sx|§" œ '·§¼Ã>v		‘	û	a
™
?v§êþ¥ö
nzœéÿJxŽ ¸-ØåH×DçÑ	¶ºRM’ñ?  © 0JN{y	§	

°
	$¦Þà } o¦(þÍ	÷	^f®Šã•… œSÉ$ž¡‡äA(	!
F
½
Ø
ð
(¼N2’j †Ëô
u˜Ñäõ]‚ŽwU	¸	@
Å
‰m�	 ,VºZm6‹	m ØH¬ú†Pbmª�
i e8u¾Â_tÚ¨
z §Ù�
Tí	¸
u‘äwÆñR�­·Ã Gã¦	ö	
 t�ÙT	Š	?
y
 ¦ØŒØ>
·
µ¶Â  )ð  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                             2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
                      	                                                              
                        
   	      
            	      2                                                                                                    
               &   "   $   
      +         %         _   *                     2                                                                                                                                                                        2                                                                                                                                                                                                                                                                                                                                                                                                                                            
        	                        
        
 	  
    	  2                                  
     & " $ 
  +   %   _ *       2   X„  Y|  Y’  Y´  \†  `n  däó.((
Q«Ë(*“ªPbþ	ð
y’f;?•ñò§Â KÝ ÙÙ|
Ï_ÿ@>­]„Û�kï/Ë !÷ŽCµ4=@=	@	x	Ú	Ü	ã	
+
4
W
Z
g
p
w
€
>«À÷Y}•ž­>]mù2â;�Œ•ë„ é  é ð0 é 
·YQ	ÀƒÜ
•Æ†
#FMBÆ” g		Úå	Ú7e°æò	’
ÊÜ
ò	ìãò	•~
¥
†È	DqÈN·	ˆNN¼a
»0;
º
¤c™£GŽ�Ý‚‹¤ \5	Ìúh;†¬	Ù	â	wÚÜ	/Â)	3Û=�ðý
‹ø=• §h	í	í	‹	ý  =2
ƒÝíÊ à®ðý
ø³Êó?¦”c¯nÉÕõƒ¬	Ù	â	é	Þ
Tp2YÖQ	ò	ó	Ô
5@LNíòr$
5)¦§8/l×T	‹	í	î	·
Å
®D?JÔ¶Ž³ ®©	ï!/ÈÙ, ·ù	“	/‡
Y}š;¤GŽGÇg$&Î;
–
¤GŽ-511À®Î *Ê =à�®ð2
ý
‹øƒE ª
w‹	®f  Ì èzCh¾Y	¯	c
s
‡
Y}‰šbiãv�‘/l®D?JŽ(wk
 ëöo	Þ
‚TíÀ
ì+
�†§í	JŽY�/F4ðý
øhk!xß¹	ú�—(Q=6Â	È	™Dq(E Î …ÊCŒt²ñD¦ŽÐ	ª
ƒ¹_*?È(æÚ¨ j8 	¹ø\.#Dû	éJòŽú
´]Ó’ ¢Ì• h	õò• òh	rÚ6Ï ’¯_ 	ëAo	‚<Éí£÷Æî¸˜×ä]wU	Å
mM? 2’ÀÞá"Å=	F	×	ý	wzêOf³[eôPRÖûQ	ˆ	ó	jçû�‡¶ÑPf§¨ýTí	î	¸
‘äÆñ�­·ÔÄ<	e2F°’™¬GüÃªPûQ	ó	çû"Å=	×	wzêO[eÞáF	ý	f³ôo(Í	÷	f…Cˆ‘
Vß:
ƒÅÑÝ¢’I	‹
w¦› âÞá"±LÂÅ1=FP=	F	~	�	×	ý	W
`
p
3>¦bwz†—êÿOfm›³çöFI�[eô�§¨¸˜ý×ä]TwU	í	î	¸
Å
‘ämÆñM�­·?v¶;	C± Œã[’ QÁMcN	æcØå° „)Î	ø	w<¿8Ûæ	¢
Û
ë
SWÿÌeÜ„AR	ô	âS d P)k�WžS�ñÀD8ÿÌe,LÛæ	¢
Û
ë
SWíÙæ,
U�ÀÊR†hÔ	;tqÐƒ	§¦
uw½2;÷�žÎ²� ‘Z ÊÏ5Ï g³+	1	^	„	�
:ÚÃÏÛ5†‰pTW}!" Hj
¨ÓYºçùÞ	Ü
8*]ÌH¬†�
\’|
p( 8”»¼`Ôž
f©±Âg¯îq 5 Ê»f©±Î²�‘ZÏÏ› â±LÂ1=FP~	�	W
`
p
3>¦b†—ÿm›çöFI���íÀÊÙæ,
RU†G I{J‹¤½YÍ
�~.ì]ÑCO©&>{� Ï (KÛ€	‚	

T
V
ˆ
¨ª¿Áÿ*Zl~–›¦o{:EKs+€�œ '·§¼Ã>v		‘	û	a
™
?v§êþ¥ö
nzœéÿJxŽâ0%ž±0L1FP½W
p
3G€5bm†—ÿçö2;FL�®÷�žë��8L	—	,O2`IJÒ´éñ?	þ
ùó™æ÷=r „ÇÕ�	­	Ú	ã	ê	
U
w
‡
‰
O©À +Y[u}•šœE|DtŠ ÃŠŒ	Bx`-£%!
äì÷Bb	p		
ß
ƒ­=UÊÆî6•š }–œN`k<RÖˆ	�	

¦
»
ù
k¥Ld�š¤ˆH�·ÒKP�ÞgƒŒ¨ú¯?ýªU	”	î	¹
’åð";Çò0Ž®¸É�F ­ �Áxll
«
}_¯‹³ì‰ { š Ë  Ty}Xä`p€–If‘œÝ,EJÒ4N`k´Çáé<HR•¯Öñ&	?	E	}	ˆ	�	
_

¦
»
Ô
î
ù
þ
5k¥Ld¬ÇÓßì=e�š¤²Ïøˆ¸áùH�·ÒûKPv�ÞóUgƒŒ™> F _ w ~ ­ » ½ Ã ù a�šÁ.fz�¾ï8xlÿh
l
«
}±_¯½‹³¾ì‰ � [*	Æ	*—Ü4‡ #/ Žÿ˜…>ÈÕhµTö¥ ]ì‚¬´6	KÍ)çûe8u¾Â_tÚ¨
z˜ å¶Ík	ž	÷
ùJ³�ÚcÏÖæIjÌ¢ î²	ÄZ) � ã %ºÓ×óU`«½I^ÁJYl¤Ò´é[ƒñ*	?	·	Æ	þ
*cˆ—Üú4cùd‡Ý <ó#™– —ôa²i	œ	�
õ
XØàþ 8\  ¾     €  —        —9=uLrˆ»U»†)Ú7Q•Y›m…ÖUâã§et–u Ša=š×\º;óV½v8jfe`;1–,mÇ[›:&Oö3Ñ(«…vP“(õ†)Ñ„`´y^¦>ëÇÛSj›Éï†Ø)í÷ŒoðtÚô&‘E›á­Uš(c84ŠøÏ
6±¯Š‰h¾©tÆÌš²ìíÖÜXYp¨(c¡‡%ƒƒâ…Ô¸�–ê�k·Á­,·¶jíèeúj¡ÄZY
&†(K³GÆ}èöù�xûJ®úÚtWªÕY‚he¾…•£J¶¡ŽÆªå´Z
Z
%ÞiÎ‡Ã¢…•±z£„¡A´mÍºüuÍ+È5MT­Vß^ß�uNíµòþÞ®Ðø&Ó]úëq·’½á2Ñÿ$UT®„oª«ŒÉn8èÕÕU÷Î}0‚¢£ÁµŸ^ê¯%àëM4gÕž/®H“É)}ëQ{‰7Ï�Ÿ³¸å¾)ôƒŽ= ÆRÈº|
µd§Á”3L, 
ÈÝÓôè�ñxF~tÈM¡3Üëñ@ECBo	L4ÐDÍÄëÐ\ø&êd¾,
³ß¸z,j¢ì´ 0O˜\ô×0ú©Â¾ª8>¨íØ®¯Œ¦ÿ†¸�—É§Ï¨HNó³Í<\|L×2÷Ó¼”¬â ìŸÌÚÐÃ@—å2'=Óé0üËìWØŠûà �( ŽÃ‹8"­¶Ð;L H�(€ ÿ´Åfáè²,g|!¥²
šmL„÷,ñÅ¨M;ƒ�'‚þLq¸ì@Ÿ=SÌËä<ð�±_×LàÕøà²$}½Ó;ÄÎÓ? /ÛÎ?\ÆÈlÏ\=ÍÜÒ 7µÏø¯s|YÌÃ%<ìÙØ0ÈÏ>°ÌòÆ|ÒžÐûaõWü=Û>\÷´nçw´÷lCÄì3cß<Î´Ñ÷'TÃ¼sÎ@ÁhÍâ±¯-
 >n¿?¶0n~<ÈÃÌÆæ<H÷3Ï¯#\r"ü9ðtÄ/3Û=tÚƒ(uõ,Í¨È.qw´ŒÏcnÌÓLÍÃMÒŒÃ3T¼ËO`Chæ9Ó9Ó9×ƒO/5TÃ2<ñC;ß›ÅÏrËÃ²Ð\Ó
ÏC�Ï1so3æÜqÄ{ óWWjÀãn|¥1ì9°1DÈÃEÐSÕC÷\SÇ[ß8®\Ö€,À
ò 
ò�p,	T¾	äªà¨câì£"¬£/*…ŸOGÀ+œ[ ±ŸSÚ¼áfÈ·ÏE°‚ˆ!‰È1{Ê$Žˆ ÛÈ30ŸFêVäBuÇ3ó¨lËŒ<}©Àº(²ƒ`<]žßÁ°@ñP±q ØÀ:èÞÃd1#”Yrƒ{1ð„²BÀp„=Ë,Ó1^„òòÌã?L”“ £Ëð«oñ¼[zÍ`õhÁ½8Ñkëm·Û}¡,rJ^Lœlxô6Õ•qPí,Tx«*›Š*/mƒÌ!-      !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  )<?xml version="1.0"?><Features nextValidID="8"><Feature recentID="7" name="Mycobacterium bovis hsp60 promoter" directionality="1" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3933-4317" color="#ccffcc" type="standard"/></Feature><Feature recentID="6" name="Feature 6" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3933-3941" color="#a6acb3" type="standard"/></Feature><Feature recentID="5" name="Mycobacterial OriM region derived from pAL5000" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2015-3910" color="#ffff99" type="standard"/></Feature><Feature recentID="4" name="Feature 4" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="2015-2048" color="#a6acb3" type="standard"/></Feature><Feature recentID="3" name="KanR" directionality="1" translationMW="30987.94" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="121-936" color="#ccffcc" type="standard" translated="1"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to kanamycin in bacteria or G418 (GeneticinÂ®) in eukaryotes&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-Ia&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="2" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1268-1856" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="1" name="rrnB T1 terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4421-4467" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator T1 from the &lt;i&gt;E. coli rrnB&lt;/i&gt; gene&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="6xHis" directionality="1" translationMW="840.86" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4380" maxFusedRunOn="4380" detectionMode="exactProteinMatch"><Segment range="4360-4377" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;6xHis affinity tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>e7eac885-dfce-48b3-ac70-46a5994322b3</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.1.16</Created>
<LastModified UTC="5:37:59">2019.8.14</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  ½       ”        ”9=uLrˆ»U»†)Ú7Q•Y›m…ÖUâã§et–u Ša=š×\º;óV½v8jfe`;1–,mÇ[›:&Oö3Ñ(«…vP“(õ†)Ñ„`´y^¦>ëÇÛSj›Éï†Ø)í÷ŒoðtÚô&‘E›á­Uš(c84ŠøÏ
6±¯Š‰h¾©tÆÌš²ìíÖÜXYp¨(c¡‡%ƒƒâ…Ô¸�–ê�k·Á­,·¶jíèeúj¡ÄZY
&†(K³GÆ}èöù�xûJ®úÚtWªÕY‚he¾…•£J¶¡ŽÆªå´Z
Z
%ÞiÎ‡Ã¢…•±z£„¡A´mÍºüuÍ+È5MT­Vß^ß�uNíµòþÞ®Ðø&Ó]úëq·’½á2Ñÿ$UT®„oª«ŒÉn8èÕÕU÷Î}0‚¢£ÁµŸ^ê¯%àëM4gÕž/®H“É)}ëQ{‰7Ï�Ÿ³¸å¾)ôƒŽ= ÆRÈº|
µd§Á”3L, 
ÈÝÓôè�ñxF~tÈM¡3Üëñ@ECBo	L4ÐDÍÄëÐ\ø&êd¾,
³ß¸z,j¢ì´ 0O˜\ô×0ú©Â¾ª8>¨íØ®¯Œ¦ÿ†¸�—É§Ï¨HNó³Í<\|L×2÷Ó¼”¬â ìŸÌÚÐÃ@—å2'=Óé0üËìWØŠûà �( ŽÃ‹8"­¶Ð;L H�(€ ÿ´Åfáè²,g|!¥²
šmL„÷,ñÅ¨M;ƒ�'‚þLq¸ì@Ÿ=SÌËä<ð�±_×LàÕøà²$}½Ó;ÄÎÓ? /ÛÎ?\ÆÈlÏ\=ÍÜÒ 7µÏø¯s|YÌÃ%<ìÙØ0ÈÏ>°ÌòÆ|ÒžÐûaõWü=Û>\÷´nçw´÷lCÄì3cß<Î´Ñ÷'TÃ¼sÎ@ÁhÍâ±¯-
 >n¿?¶0n~<ÈÃÌÆæ<H÷3Ï¯#\r"ü9ðtÄ/3Û=tÚƒ(uõ,Í¨È.qw´ŒÏcnÌÓLÍÃMÒŒÃ3T¼ËO`Chæ9Ó9Ó9×ƒO/5TÃ2<ñC;ß›ÅÏrËÃ²Ð\Ó
ÏC�Ï1so3æÜqÄ{ óWWjÀãn|¥1ì9°1DÈÃEÐSÕC÷\SÇ[ß8®\Ö€,À
ò 
ò�p,	T¾	äªà¨câì£"¬£/*…ŸOGÀ+œ[ ±ŸSÚ¼áfÈ·ÏE°‚ˆ!‰È1{Ê$Žˆ ÛÈ30ŸFêVäBuÇ3ó¨lËŒ<}©Àº(²ƒ`<]žßÁ°@ñP±q ØÀ:èÞÃd1#”Yrƒ{1ð„²BÀp„=Ë,Ó1^„òòÌã?L”“ £Ëð«oñ¼[zÍ`õhÁ½8Ñkëm·Û}‹’—“'=µe\T;KêÊ¦âŠ‹ÃÛ`óm      !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  )<?xml version="1.0"?><Features nextValidID="8"><Feature recentID="7" name="6xHis" directionality="1" translationMW="840.86" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4395" maxFusedRunOn="4395" detectionMode="exactProteinMatch"><Segment range="4360-4377" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;6xHis affinity tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="6" name="rrnB T1 terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4418-4464" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator T1 from the &lt;i&gt;E. coli rrnB&lt;/i&gt; gene&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1268-1856" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="4" name="KanR" directionality="1" translationMW="30987.94" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="121-936" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-Ia&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to kanamycin in bacteria or G418 (GeneticinÂ®) in eukaryotes&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="3" name="Feature 4" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="2015-2048" color="#a6acb3" type="standard"/></Feature><Feature recentID="2" name="Mycobacterial OriM region derived from pAL5000" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2015-3910" color="#ffff99" type="standard"/></Feature><Feature recentID="1" name="Feature 6" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3933-3941" color="#a6acb3" type="standard"/></Feature><Feature recentID="0" name="Mycobacterium bovis hsp60 promoter" directionality="1" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3933-4317" color="#ccffcc" type="standard"/></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>fe024689-469c-47e3-b438-03c80ae26e8e</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.1.16</Created>
<LastModified UTC="3:55:41">2019.8.12</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Î      t  ˆ         ˆ9=uLrˆ»U»†)Ú7Q•Y›m…ÖUâã§et–u Ša=š×\º;óV½v8jfe`;1–,mÇ[›:&Oö3Ñ(«…vP“(õ†)Ñ„`´y^¦>ëÇÛSj›Éï†Ø)í÷ŒoðtÚô&‘E›á­Uš(c84ŠøÏ
6±¯Š‰h¾©tÆÌš²ìíÖÜXYp¨(c¡‡%ƒƒâ…Ô¸�–ê�k·Á­,·¶jíèeúj¡ÄZY
&†(K³GÆ}èöù�xûJ®úÚtWªÕY‚he¾…•£J¶¡ŽÆªå´Z
Z
%ÞiÎ‡Ã¢…•±z£„¡A´mÍºüuÍ+È5MT­Vß^ß�uNíµòþÞ®Ðø&Ó]úëq·’½á2Ñÿ$UT®„oª«ŒÉn8èÕÕU÷Î}0‚¢£ÁµŸ^ê¯%àëM4gÕž/®H“É)}ëQ{‰7Ï�Ÿ³¸å¾)ôƒŽ= ÆRÈº|
µd§Á”3L, 
ÈÝÓôè�ñxF~tÈM¡3Üëñ@ECBo	L4ÐDÍÄëÐ\ø&êd¾,
³ß¸z,j¢ì´ 0O˜\ô×0ú©Â¾ª8>¨íØ®¯Œ¦ÿ†¸�—É§Ï¨HNó³Í<\|L×2÷Ó¼”¬â ìŸÌÚÐÃ@—å2'=Óé0üËìWØŠûà �( ŽÃ‹8"­¶Ð;L H�(€ ÿ´Åfáè²,g|!¥²
šmL„÷,ñÅ¨M;ƒ�'‚þLq¸ì@Ÿ=SÌËä<ð�±_×LàÕøà²$}½Ó;ÄÎÓ? /ÛÎ?\ÆÈlÏ\=ÍÜÒ 7µÏø¯s|YÌÃ%<ìÙØ0ÈÏ>°ÌòÆ|ÒžÐûaõWü=Û>\÷´nçw´÷lCÄì3cß<Î´Ñ÷'TÃ¼sÎ@ÁhÍâ±¯-
 >n¿?¶0n~<ÈÃÌÆæ<H÷3Ï¯#\r"ü9ðtÄ/3Û=tÚƒ(uõ,Í¨È.qw´ŒÏcnÌÓLÍÃMÒŒÃ3T¼ËO`Chæ9Ó9Ó9×ƒO/5TÃ2<ñC;ß›ÅÏrËÃ²Ð\Ó
ÏC�Ï1so3æÜqÄ{ óWWjÀãn|¥1ì9°1DÈÃEÐSÕC÷\SÇ[ß8®\Ö€,À
ò 
ò�p,	T¾	äªà¨câì£"¬£/*…ŸOGÀ+œ[ ±ŸSÚ¼áfÈ·ÏE°‚ˆ!‰È1{Ê$Žˆ ÛÈ30ŸFêVäBuÇ3ó¨lËŒ<}©Àº(²ƒ`<]žßÁ°@ñP±q ØÀ:èÞÃd1#”Yrƒ{1ð„²BÀp„=Ë,Ó1^„òòÌã?L”“ £Ëð«oñ¼[zÍ`õhÁ½8Ñké±‹’—“'=µe\T;KêÊ¦âŠ‹ÃÛ`óm  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  	E<?xml version="1.0"?><Features nextValidID="7"><Feature recentID="6" name="rrnB T1 terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4406-4452" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator T1 from the &lt;i&gt;E. coli rrnB&lt;/i&gt; gene&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1268-1856" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="4" name="KanR" directionality="1" translationMW="30987.94" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="121-936" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-Ia&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to kanamycin in bacteria or G418 (GeneticinÂ®) in eukaryotes&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="3" name="Feature 4" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="2015-2048" color="#a6acb3" type="standard"/></Feature><Feature recentID="2" name="Mycobacterial OriM region derived from pAL5000" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2015-3910" color="#ffff99" type="standard"/></Feature><Feature recentID="1" name="Feature 6" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3933-3941" color="#a6acb3" type="standard"/></Feature><Feature recentID="0" name="Mycobacterium bovis hsp60 promoter" directionality="1" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3933-4317" color="#ccffcc" type="standard"/></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>fe024689-469c-47e3-b438-03c80ae26e8e</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.1.16</Created>
<LastModified UTC="3:55:32">2019.8.12</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
   ý7zXZ  æÖ´F !   t/å£à ñÞ] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷Ànæôg<½´)îœ=˜M"^‹RUž¯ÿÆ(õ ¬§¢)¥rœm�¢15èkŒà¹oœ�‰„XÄyüL½[å³/<dõëX�[$ÚŽÙ2]ç_Trrl¦‡óÝõ±$Øy»Ôfã=-J-e÷j(qÜJ,k©œ)/B½8™Õý.NMkÌÌúÞæëSÕµóDo¡îT^2©LG¼u…<zà,¤ŠÏêïúæ£Õå~3ï*¸Ñkwƒµ÷MqCKpŸ>q85"è­×ÁÑn¾Šyaµ¼Àäÿeç£¯EYª“»NÕ?kè²cü{Ñc¬Œ®ð¯âGõûd{ŒBÐ¤;2ð$D��¿€Œš¬Y)¹Rœ¸áV¤aÕ0[õ�oq&óÒ@<¯ ³rü&äÀ|ã1±Üb·÷* z…[ëãñÎfYÙi(fÃG–>=2]"Ø�^öSSÎh–2Öéõ�hÙœnîµ–~¥‰†µ©…“,ó°Ž€ð°¶Á|ŸŒ4£ê=ã/+áFz\u…*_ËèÞ-p¢e•%Åkíµ¦yTÀ2óÆ°òçþ^ù†LdÚé�jÍ”`ËCjô¶0l÷µ2n¤?ŠØ×àç¦º»�‰¼°e)SMÆì>�H•Y�°©„K£EþEïÔíN«Éd�–—+Â1�ßT	¥}J™¾­ 	¨"H#Nµ¦ˆÀe¬»æj¨;m398®m¯†‚Þ_î˜2?3?7“’gÀõUmë]/w5ŽrC|bú‹Ãè¨hõ±>R}J;E_�ÁˆyìQfmGò©CýŒ·ù™µ¢ÇÁ
×åFçäà ‡ç-6ud¨}p·ýŽJ°HK¥Ý#V#•hKãUs?!/|ÐñÛ@(W ›;'Ì( ŒÀÚJLŽ2s³pÌ5öÛåäißV×åJÕ.
]r•ãŒaò5t_ cÇFabÜEáú'Gu“�jª…�¨ŠØ?ÅÆH|‹<‰ ^ùõ£Ò�â§—WÑáÄãb�oÀ|/èwtÊÝº¸¾‹cÜÅ”ûOøŸÞ"(Ùïc�”òVÎ 3�¥5ãß„Ñcw·(mâ\35ú+Ö;X$5ÃGæì¦´+ÀuïË
‹‹A×±,,N€‹ÚŽØ8[K”Ú0¾7ì‡–¡ŠŠö]QWöCÌ’9äñh6' ²pòëL›
“×{¬p_J±=�ñ0R^¤KûeWÖ¬)ýn‚Ú‡ŸšeýøãÑBK´¤B;Ÿ Õå£fî£F¬‰ïžÌ Ä²hÖtF®¹h~8m½€´¸~¯D
§¹®·Ñ0ß?\˜ˆ K\þÅÃ¨„éæí'üëbhÔÒãQà€„¬1¾væÛbUði°�«Ùš¶·³§	ö*o¦¿*]%ˆ¿þBË¢ ÅÍûüáì‹
vh Tö Új3?–éh@£Ùu.z(ÎpN@­jüùDíO¦‹,»huyk¿$Ü¸4þÿ­³Ë™ØŽÑ¥NÃè	Hºr«4‚ª‹‹\Å4™(     Š„÷/$Ê¢ ú	òA  µ{'±Ägû    YZ  5      ,®ZTR

BASE      ƒ  xÁA  ƒ°YëñÀ þµ,9jÊV#«e›Ì1«VËåZ«jQ&[¶±˜sUÎ16L©   ‡1Mi’‹�(,—²¶·)0£Â‘*¬ZåRf¸°!ÍÚhŽØÒ\šË%k“Â­H&éÙÊ(…•¸™+t¡ºÜ†ª1Ps(€4jH
*2‡%6Ë $a„$‡
)ÄÀ MF4Ä™°a­¨É¡%8“ÍM ¨±e
.Ps¶,X„ÇÆæ Û–†‚Ìa .¶‰ŠX¦10š«¶¹Hˆ‚C—0SFcCg!‹ÁØ`àŠÍI ®Ý–RÚÂÁæ
›€FJÚŠmCE6ÜÆ�÷Œyú¤  6     -®ZTR

BASE      „  xÁA  ƒ°YãúÀ þµ,¹i²ÍŠ¶MÚ¥±šƒt”SÚp9„šàŠ&Ùd†gLš,7t4 €	è6YêVÍ*r£‘nN“†7¶d6UUpc–Ù@kI£	€ˆF#aÀ²åŠ0b šEâFÔ`*0[¹&º9) 6)¹¤"R# uÍI�M44'ƒÍ•‘
n97Ä²Z# á,7H²’HÚ�,]2…ŠÜZm²ÑÀQE›±¶$É‘kl,'m›
0µ¡QB´%54¢,É¹t˜µåÜ´5©-+ƒ²­
†“æŒj¶æ:�		Á´Ò’œ˜TI2qéÒ-KØR@ GÐªÜ¨k‹üÒ  5<AlignableSequences trimStringency="Medium"><Sequence name="102_kan-r_tss20190921-027-6729_d10  (Start (0) .. End (898))" ID="0" sortOrder="0" trimmedRange="0..888"/><Sequence name="59_261-F1_TSS20190909-027-2575_G03  (Start (0) .. End (899))" ID="1" sortOrder="1" trimmedRange="0..898"/></AlignableSequences>  Ü‹     ÿ BC N srôe”```pðpáó³2Ô3ãö·²*Í+Î/*IMábÊqqQjZjQj^r*Ã,A 4#«6   ‹     ÿ BC píU1®7”8M`û“PÁV!•ã˜æANà#X4•.’Â�ÀWÉ_Äáú»I¤ýEÞ`µÔòI¢8x˜y÷¸}ÅO[ûîË/ø¤Ýµø¾ýÏ[{ÒÔìÏ/jüÚ[ÃŠïlísÅO�Z“³æohí÷ŠáÉy®÷äs„pèîhv
­t®\Ÿt¦&ì0ëkÌZCìvÜ’ÝÖôÜ®«2J³2¬ÌŽCâlˆ-ì2¸ª¬#u
úR›Rç¢ùÊã|Œ}då�0p±˜r—Ñ��»)ÉdW³G1llãž„ öŽÅŒUÄu[ØUÎf×éÚkÙõ’�G”£R¦x5¬C¼³yNóºc±4§DU‡ÀÃƒl‚J–šÕxH_;GÐ˜×“=„·oÜê(!K‡� `èõ+È2]§ø%­m6µhºuÌDg» }¢gF D©{T“ `ïª”0êÀU¤$À¾	Á|wÃ/7ÜpÃâÃ7qþxw/ÎÏjþæâüs{ûM”_¶{Q¾{t_ÕJ©ø[}¿züo¡¾û©µK˜øì˜LÓºü‡,…äC©‘å!Ñ±Ï@àé(V9@1�Œ4é™�i¨lªjƒ†%cYDèq2és’–¿x¹RBí`ÕKNøzÉN7,[ÂRGêZÁXM*G¼×L’é»œªt¾ä¼.„}œÙ�¶ô²±%§êV;Ç³Ê•?ä™e	v´ˆ¬éÉMëlìLÌ»,rñVÄ†rB´“×^q)ßL”²’¬ƒ–;=²x†›ÖÉI¯ú?zÃÿsüèÆ«D  ‹     ÿ BC             !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ‹<?xml version="1.0"?><Features nextValidID="8"><Feature recentID="0" name="Mycobacterium bovis hsp60 promoter" directionality="1" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3933-4317" color="#ccffcc" type="standard"/></Feature><Feature recentID="1" name="Feature 6" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3933-3941" color="#a6acb3" type="standard"/></Feature><Feature recentID="2" name="Mycobacterial OriM region derived from pAL5000" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2015-3910" color="#ffff99" type="standard"/></Feature><Feature recentID="3" name="Feature 4" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="2015-2048" color="#a6acb3" type="standard"/></Feature><Feature recentID="4" name="KanR" directionality="1" translationMW="30987.94" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="121-936" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-Ia&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to kanamycin in bacteria or G418 (GeneticinÂ®) in eukaryotes&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSHIQRETSCSRPRLNSNMDADLYGYKWARDNVGQSGATIYRLYGKPHAPELFLKHGKGSVANDVTDEMVRLNWLTEFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHNLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF*"/></Q></Feature><Feature recentID="5" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1268-1856" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="rrnB T1 terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4424-4470" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator T1 from the &lt;i&gt;E. coli rrnB&lt;/i&gt; gene&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="6xHis" directionality="1" translationMW="840.86" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="4383" maxFusedRunOn="4383" detectionMode="exactProteinMatch"><Segment range="4363-4380" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;6xHis affinity tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="HHHHHH"/></Q></Feature></Features>
  3<?xml version="1.0"?><Primers nextValidID="2"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="R1" sequence="TCGACtcaatggtgatggtgatgatgcatA" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="4358-4387" boundStrand="1" annealedBases="TCGACtcaatggtgatggtgatgatgcatA" meltingTemperature="63"><Component hybridizedRange="4358-4387" bases="TCGACtcaatggtgatggtgatgatgcatA"/></BindingSite><BindingSite simplified="1" location="4358-4387" boundStrand="1" annealedBases="TCGACtcaatggtgatggtgatgatgcatA" meltingTemperature="63"><Component hybridizedRange="4358-4387" bases="TCGACtcaatggtgatggtgatgatgcatA"/></BindingSite></Primer><Primer recentID="1" name="F1" sequence="AGCTTatgcatcatcaccatcaccattgaG" description="&lt;html&gt;&lt;body&gt;&lt;/body&gt;&lt;/html&gt;"><BindingSite location="4354-4383" boundStrand="0" annealedBases="AGCTTatgcatcatcaccatcaccattgaG" meltingTemperature="63"><Component hybridizedRange="4354-4383" bases="AGCTTatgcatcatcaccatcaccattgaG"/></BindingSite><BindingSite simplified="1" location="4354-4383" boundStrand="0" annealedBases="AGCTTatgcatcatcaccatcaccattgaG" meltingTemperature="63"><Component hybridizedRange="4354-4383" bases="AGCTTatgcatcatcaccatcaccattgaG"/></BindingSite></Primer></Primers>
  ˜<Notes>
<UUID>e8791377-8988-4e29-9fae-92f03845abeb</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pMV261-6Ã—His</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="16:0:0">2017.1.16</Created>
<LastModified UTC="4:51:30">2025.8.27</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y      K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                              ³<StrandColors><TopStrand><ColorRange range="4470..4484" colors="magenta"/></TopStrand><BottomStrand><ColorRange range="4470..4484" colors="magenta"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
